The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Functional spliceosome associated protein 24
Functional spliceosome-associated protein 24
Ngg1 interacting factor 3 like 1 binding protein 1
Ngg1 interacting factor 3 like protein 1 binding protein 1
Ngg1-interacting factor 3-like protein 1-binding protein 1
NIF3L1 binding protein 1
NIF3L1-binding protein 1
THO complex 7 homolog
THO complex 7 homolog (Drosophila)
THO complex subunit 7 homolog
Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4.
Belongs to the THOC7 family.
Cytoplasm. Nucleus. Interaction with THOC5 is required for nuclear localization.