Recombinant Human Thyroid Hormone Receptor alpha 1 protein (ab82120)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab82120 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab82120 is greater than 95% homogeneous based on SDS-PAGE analysis, purified by a combination of affinity and gel filtration chromatography.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

General Info

  • Alternative names
    • c-erbA-1
    • C-erbA-alpha
    • EAR-7
    • ERBA
    • Nuclear receptor subfamily 1 group A member 1
    • THA_HUMAN
    • THRA
    • Thra1
    • Thyroid hormone receptor alpha
    • Thyroid hormone receptor alpha 1
    • TR alpha 1
    • V-erbA-related protein 7
    see all
  • FunctionNuclear hormone receptor. High affinity receptor for triiodothyronine.
  • Involvement in diseaseHypothyroidism, congenital, non-goitrous, 6 (CHNG6) [MIM:614450]: A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Recombinant Human Thyroid Hormone Receptor alpha 1 protein (ab82120)

ab82120 has not yet been referenced specifically in any publications.

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