Recombinant Human Thyroid Hormone Receptor beta protein (ab82049)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Additional sequence informationThis protein is His-tagged.

Specifications

Our Abpromise guarantee covers the use of ab82049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

General Info

  • Alternative names
    • Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2
    • C ERBA 2
    • C ERBA BETA
    • c-erbA-2
    • c-erbA-beta
    • ERBA 2
    • ERBA BETA
    • ERBA2
    • Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian
    • generalized resistance to thyroid hormone
    • GRTH
    • MGC126109
    • MGC126110
    • NR1A2
    • Nuclear receptor subfamily 1 group A member 2
    • Oncogene ERBA2
    • PRTH
    • THB_HUMAN
    • THR1
    • thrB
    • THRB 1
    • THRB 2
    • THRB1
    • THRB2
    • Thyroid hormone nuclear receptor beta variant 1
    • Thyroid hormone receptor beta
    • Thyroid hormone receptor beta 1
    • Thyroid hormone receptor beta 2
    • Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian)
    see all
  • FunctionHigh affinity receptor for triiodothyronine.
  • Involvement in diseaseDefects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
    Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt

Recombinant Human Thyroid Hormone Receptor beta protein images

  • SDS-PAGE analysis of Human Thyroid Hormone Receptor beta full length protein (ab82049).

References for Recombinant Human Thyroid Hormone Receptor beta protein (ab82049)

ab82049 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your phone call last week and for your patience while I have been in touch with the production lab regarding ab82049.
At this point, we are not sure why the protein would not be visible on the gel. Have you repeated the assay, and if...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"