Recombinant Human TIE1 protein (Fc Chimera) (ab73870)

Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus
  • Amino Acid Sequence
    • Species
      Human
    • Additional sequence information
      Fused with the Fc part of human IgG1.

Specifications

Our Abpromise guarantee covers the use of ab73870 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.
    ab73870 is purified by proprietary chromatographic techniques. Purity is greater than 90.0% as determined by RP-HPLC and SDS-PAGE.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Sucrose, 0.5M Sodium chloride, 20mM Tris

  • Reconstitution
    Reconstitute in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions. Upon reconstitution ab73870 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

General Info

  • Alternative names
    • JKT 14
    • JTK14
    • TIE
    • Tie1
    • TIE1_HUMAN
    • Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains
    • Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
    • Tyrosine kinase with immunoglobulin-like and EGF-like domains 1
    • Tyrosine protein kinase receptor Tie 1
    • Tyrosine-protein kinase receptor Tie-1
    see all
  • Function
    Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
  • Tissue specificity
    Specifically expressed in developing vascular endothelial cells.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
    Contains 3 EGF-like domains.
    Contains 3 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab73870 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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