The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab73870 is purified by proprietary chromatographic techniques.
Purity is greater than 90.0% as determined by RP-HPLC and SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 10% Sucrose, 0.5M Sodium chloride, 20mM Tris
ReconstitutionReconstitute in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Upon reconstitution ab73870 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains
Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Tyrosine protein kinase receptor Tie 1
Tyrosine-protein kinase receptor Tie-1
FunctionTransmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Tissue specificitySpecifically expressed in developing vascular endothelial cells.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. Contains 3 EGF-like domains. Contains 3 fibronectin type-III domains. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
Post-translational modificationsPhosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.