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Alternative names
- Clgi
- Collagenase inhibitor
- Collagenase inhibitor, Human
- EPA
- EPO
- Erythroid Potentiating Activity
- Erythroid-potentiating activity
- Fibroblast collagenase inhibitor
- FLJ90373
- HCI
- Human Collagenase Inhibitor
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 1 precursor
- OTTHUMP00000023214
- TIMP
- TIMP 1
- TIMP metallopeptidase inhibitor 1
- TIMP-1
- Timp1
- TIMP1 protein
- TIMP1_HUMAN
- Tissue Inhibitor of Metalloproteinase 1
- Tissue inhibitor of metalloproteinases
- Tissue inhibitor of metalloproteinases 1
- Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor
see all
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Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
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Sequence similarities
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.
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Post-translational
modifications
The activity of TIMP1 is dependent on the presence of disulfide bonds.
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Cellular localization
Secreted.
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Information by UniProt