Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids388 to 772

Associated products

Specifications

Our Abpromise guarantee covers the use of ab89855 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe specific activity of ab89855 was determined to be 79 nmol/min/mg
  • Applications

    SDS-PAGE

    Western blot

    Functional Studies

  • Purity> 90 % SDS-PAGE.

  • FormLiquid
  • Additional notes

    ab91092 (Cow Casein full length protein) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • MGC44450
    • PKU alpha
    • PKU-alpha
    • Serine/threonine kinase
    • Serine/threonine protein kinase tousled like 2
    • Serine/threonine-protein kinase tousled-like 2
    • TLK 2
    • tlk2
    • TLK2_HUMAN
    • Tousled like kinase 2
    • Tousled-like kinase 2
    see all
  • FunctionRapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.
  • Tissue specificityWidely expressed. Present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. Also found in adult cell lines.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Cellular localizationNucleus.
  • Information by UniProt

Recombinant human TLK2 protein images

  • SDS-PAGE showing ab89855 at approximately 67kDa
  • Kinase Assay demonstrating specific activity of ab89855

References for Recombinant human TLK2 protein (ab89855)

ab89855 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89855.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"