This product is an active protein and may elicit a biological response in vivo, handle with caution.
Serine/threonine protein kinase tousled like 2
Serine/threonine-protein kinase tousled-like 2
Tousled like kinase 2
Tousled-like kinase 2
FunctionRapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.
Tissue specificityWidely expressed. Present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. Also found in adult cell lines.
Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.