Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionO60603
    • SpeciesHuman
    • SequenceSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSL IKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN
    • Molecular weight37 kDa including tags
    • Amino acids201 to 300

Specifications

Our Abpromise guarantee covers the use of ab112361 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • FormLiquid
  • Additional notesBest use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • CD282
    • CD282 antigen
    • TIL 4
    • TIL4
    • TLR 2
    • TLR2
    • TLR2_HUMAN
    • Toll like receptor 2
    • Toll like receptor 2 precursor
    • Toll-like receptor 2
    • Toll/interleukin 1 receptor like 4
    • Toll/interleukin 1 receptor like protein 4
    • Toll/interleukin receptor like protein 4
    • Toll/interleukin-1 receptor-like protein 4
    see all
  • FunctionCooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
  • Tissue specificityHighly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
  • Sequence similaritiesBelongs to the Toll-like receptor family.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • Post-translational
    modifications
    Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant Human TLR2 protein images

  • ab112361 on a 12.5% SDS-PAGE Stained with Coomassie Blue.

References for Recombinant Human TLR2 protein (ab112361)

ab112361 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112361.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"