The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological Activity: Binds to TNF Receptor I and triggers various biological effects (including cell death). ab157278 blocks TNF-alpha-mediated lysis with a inhibitory activity in a concentration range of 10-50ng/ml.
< 0.100 Eu/µg
>95% by SDS-PAGE .
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20ºC.
Constituent: 99% PBS
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute with 50µl sterile water to a concentration of 1 mg/ml. Further dilutions should be made with medium containing 5% fetal calf serum or carrier protein.
After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Tumor necrosis factor receptor 1
Tumor necrosis factor receptor superfamily, member 1A
Tumor necrosis factor receptor type 1
Tumor necrosis factor receptor type I
Tumor necrosis factor-binding protein 1
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Involvement in disease
Familial hibernian fever Multiple sclerosis 5
Contains 1 death domain. Contains 4 TNFR-Cys repeats.
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE. Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
The soluble form is produced from the membrane form by proteolytic processing.
Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.