The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological Activity : Determined by its ability to neutralize 0.25 ng/ml of hTNFbeta induced cytotoxicity on murine L929 cells. The expected ED50 for this effect is 1.3-1.9 µg/ml of TNFRSF14.
% SDS-PAGE. Source : Insect cells.
Purity : Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
CD40 like protein precursor
Herpes virus entry mediator A
Herpesvirus entry mediator
Herpesvirus entry mediator A
Herpesvirus entry mediator ligand
Tumor necrosis factor receptor like gene2
Tumor necrosis factor receptor superfamily member 14
Tumor necrosis factor receptor superfamily member 14 precursor
Tumor necrosis factor receptor-like 2
FunctionReceptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
Tissue specificityWidely expressed, with the highest expression in lung, spleen and thymus.