The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activity: Use at a concentration of 1 - 10 ng/ml to stimulate IL8 production by human PBMC. Results may vary with PBMC donors.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. Greater than 98% by SDS-PAGE and HPLC analyses.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4oC for 1 week or -20oC for future use.
Activation inducible TNF related ligand
Activation-inducible TNF-related ligand
Glucocorticoid induced TNF related ligand
Glucocorticoid induced TNFR related protein ligand
Glucocorticoid-induced TNF-related ligand
Tumor necrosis factor (ligand) superfamily member 18
Tumor necrosis factor ligand 2A
Tumor necrosis factor ligand superfamily member 18
FunctionCytokine that binds to TNFRSF18/AITR/GITR. Important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues.
Tissue specificityExpressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Sequence similaritiesBelongs to the tumor necrosis factor family.