Recombinant Human Tollip protein (ab107146)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMATTVSTQRGPVYIGELPQDFLRITPTQQQ RQVQLDAQAAQQLQYGGAVGTVGRLNITVVQAKLAKNYGMTRMDPYCRLR LGYAVYETPTAHNGAKNPRWNKVIHCTVPPGVDSFYLEIFDERAFSMDDR IAWTHITIPESLRQGKVEDKWYSLSGRQGDDKEGMINLVMSYALLPAAMV MPPQPVVLMPTVYQQGVGYVPITGMPAVCSPGMVPVALPPAAVNAQPRCS EEDLKAIQDMFPNMDQEVIRSVLEAQRGNKDAAINSLLQMGEEP
    • Molecular weight
      32 kDa including tags
    • Amino acids
      1 to 294
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab107146 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 85 % SDS-PAGE.
    Purified by using conventional chromatography
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 40% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

General Info

  • Alternative names
    • Adapter protein
    • FLJ33531
    • IL 1RAcPIP
    • IL1RAcPIP
    • TOLIP
    • TOLIP_HUMAN
    • Toll interacting protein
    • Toll-interacting protein
    • tollip
    see all
  • Function
    Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.
  • Sequence similarities
    Belongs to the tollip family.
    Contains 1 C2 domain.
    Contains 1 CUE domain.
  • Post-translational
    modifications
    Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • ab107146 at 3 µg analysed by 15% SDS PAGE.

References

ab107146 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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