The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Antigen MLAA 44
DNA topoisomerase 2 beta
DNA topoisomerase 2-beta
DNA topoisomerase II
DNA topoisomerase II 180 kD
DNA topoisomerase II beta
DNA topoisomerase II beta isozyme
Topo II beta
Topoisomerase (DNA) II beta
Topoisomerase (DNA) II beta 180kDa
U937 associated antigen
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly ivolved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
Belongs to the type II topoisomerase family.
Phosphorylated upon DNA damage, probably by ATM or ATR.