Recombinant Human TRIM37 protein (ab116888)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      GHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGMSSDSDIECDTENEE QEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDENSGR
    • Molecular weight
      37 kDa including tags
    • Amino acids
      865 to 964

Specifications

Our Abpromise guarantee covers the use of ab116888 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    SDS-PAGE

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • E3 ubiquitin protein ligase TRIM37
    • E3 ubiquitin-protein ligase TRIM37
    • KIAA0898
    • MUL
    • MUL protein
    • Mulibrey nanism gene
    • Mulibrey nanism protein
    • POB 1
    • POB1
    • RING B box coiled coil protein
    • TEF 3
    • TEF3
    • TRI37_HUMAN
    • TRIM 37
    • Trim37
    • Tripartite motif containing 37
    • Tripartite motif containing 37 protein
    • Tripartite motif containing protein 37
    • Tripartite motif-containing protein 37
    see all
  • Function
    E3 ubiquitin-protein ligase.
  • Tissue specificity
    Ubiquitous.
  • Pathway
    Protein modification; protein ubiquitination.
  • Involvement in disease
    Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.
  • Sequence similarities
    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 MATH domain.
    Contains 1 RING-type zinc finger.
  • Post-translational
    modifications
    Auto-ubiquitinated.
  • Cellular localization
    Cytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab116888 at approximately 36.63kDa stained with Coomassie Blue

References

ab116888 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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