This product is an active protein and may elicit a biological response in vivo, handle with caution.
ETS related protein neurotrophic receptor tyrosine kinase fusion
ETS related protein neurotrophic receptor tyrosine kinase fusion protein
ETV6 NTRK3 fusion
Neurotrophic tyrosine kinase receptor type 3
Neurotrophin 3 receptor
NT 3 growth factor receptor
NT 3 growth factor receptor precursor
NT 3 receptor
NT-3 growth factor receptor
TrkC tyrosine kinase
Tyrosine kinase receptor C
FunctionReceptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Tissue specificityWidely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain.