The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C.
Constituents: 10% Trehalose, 1% Human serum albumin, PBS
ReconstitutionReconstitution: It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
ETS related protein neurotrophic receptor tyrosine kinase fusion
ETS related protein neurotrophic receptor tyrosine kinase fusion protein
ETV6 NTRK3 fusion
Neurotrophic tyrosine kinase receptor type 3
Neurotrophin 3 receptor
NT 3 growth factor receptor
NT 3 growth factor receptor precursor
NT 3 receptor
NT-3 growth factor receptor
TrkC tyrosine kinase
Tyrosine kinase receptor C
FunctionReceptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Tissue specificityWidely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain.
Recombinant Human TrkC protein (Fc Chimera) images
SDS-PAGE - TrkC – Fc Chimera (ab85599)
1D SDS-PAGE of ab85599 before and after treatment with glycosidases to remove oligosaccharides.
Lane 1: ab85599
Lane 2: ab85599 treated with PNGase F to remove potential N-linked glycans
Lane 3: ab85599 treated with a glycosidase cocktail to remove potential N- and O-linked glycans. 5 mg of protein was loaded per lane. Gel was stained with Deep Purple™.
Drop in MW after treatment with PNGase F indicates presence of N-linked glycans. Subsequent tightening of bands after treatment with glycosidase cocktail suggests the presence of O-linked glycans.
Functional Studies - TrkC – Fc Chimera (ab85599)
Densitometry of protein isoforms visualised by 2-DE.
The densitometry scan demonstrates the purified Human cell expressed protein exists in multiple isoforms, which differ according to their level of post-translational
The triangle indicates the theoretical MW and pI of the protein.
References for Recombinant Human TrkC protein (Fc Chimera) (ab85599)
has not yet been referenced specifically in any publications.
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