Recombinant Human Tropomyosin 3 protein (ab112675)



  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP06753
    • SpeciesHuman
    • Molecular weight41 kDa


Our Abpromise guarantee covers the use of ab112675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    pH: 6.80
    Constituents: 1.58% Tris HCl, 3.09% DTT, 4% SDS, 0.2% Bromophenol blue, 20% Sucrose

  • ReconstitutionAdd 200ul of distilled water.

General Info

  • Alternative names
    • Alpha tropomyosin 3
    • Alpha tropomyosin slow skeletal
    • CFTD
    • Cytoskeletal tropomyosin TM30
    • FLJ41118
    • gamma TM
    • Gamma tropomyosin
    • Gamma-tropomyosin
    • Heat stable cytoskeletal protein 30 kDa
    • hscp30
    • hTM30nm
    • hTM5
    • hTMnm
    • MGC102590
    • MGC14582
    • MGC3261
    • MGC72094
    • NEM1
    • OK/SW-cl.5
    • OTTHUMP00000034019
    • OTTHUMP00000034171
    • OTTHUMP00000034172
    • TM 5
    • TM-5
    • TM3
    • TM30
    • TM30nm
    • TM5
    • Tm5NM
    • Tpm 5
    • TPM3
    • TPM3_HUMAN
    • Tpm5
    • TPMsk3
    • TRK
    • Trop 5
    • Tropomyosin 3
    • Tropomyosin 3 gamma
    • Tropomyosin 5
    • Tropomyosin alpha 3 chain
    • Tropomyosin alpha-3 chain
    • Tropomyosin gamma
    • Tropomyosin-3
    • Tropomyosin-5
    see all
  • FunctionBinds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
  • Involvement in diseaseDefects in TPM3 are the cause of nemaline myopathy type 1 (NEM1) [MIM:609284]. A form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Autosomal dominant nemaline myopathy type 1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate-to-severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years.
    Defects in TPM3 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TPM3 is found in thyroid papillary carcinomas. A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.
  • Sequence similaritiesBelongs to the tropomyosin family.
  • DomainThe molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • Cellular localizationCytoplasm > cytoskeleton.
  • Information by UniProt

References for Recombinant Human Tropomyosin 3 protein (ab112675)

ab112675 has not yet been referenced specifically in any publications.

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