Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP

Specifications

Our Abpromise guarantee covers the use of ab95505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • Beckwith Wiedemann syndrome chromosome region 1 candidate protein C
    • Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein
    • BRW 1C
    • BRW1C
    • BWR 1C
    • BWR1C
    • HLDA 2
    • HLDA2
    • Imprinted in placenta and liver
    • Imprinted in placenta and liver protein
    • IPL
    • p17 Beckwith Wiedemann region 1C
    • p17 BWR1C
    • p17-Beckwith-Wiedemann region 1 C
    • p17-BWR1C
    • PHLA2_HUMAN
    • PHLDA 2
    • phlda2
    • Pleckstrin homology like domain family A member 2
    • Pleckstrin homology-like domain family A member 2
    • TSSC 3
    • Tumor suppressing STF cDNA 3 protein
    • Tumor suppressing subchromosomal transferable fragment candidate gene 3 protein
    • Tumor suppressing subchromosomal transferable fragment cDNA 3
    • Tumor suppressing subtransferable candidate 3
    • Tumor supressing STF cDNA 3
    • Tumor-suppressing STF cDNA 3 protein
    • Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein
    see all
  • FunctionPlays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
  • Tissue specificityExpressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.
  • Sequence similaritiesBelongs to the PHLDA2 family.
    Contains 1 PH domain.
  • DomainThe PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3).
  • Cellular localizationCytoplasm. Membrane.
  • Information by UniProt

Recombinant Human TSSC3 protein images

  • 15% SDS-PAGE showing ab95505 at approximately 19.2kDa (3µg).

References for Recombinant Human TSSC3 protein (ab95505)

ab95505 has not yet been referenced specifically in any publications.

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