FunctionPromotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
Sequence similaritiesBelongs to the FIS1 family. Contains 1 TPR repeat.
DomainThe C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.
Post-translational modificationsUbiquitinated by MARCH5.