The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityDetermined by its ability to inhibit TWEAKR induced weak cell death of HT29 cells, with an expected ED50 of 1.0-3.0 µg/ml.
Endotoxin level< 1.000 Eu/µg
% SDS-PAGE. Purity is determined to be >98% by SDS PAGE and HPLC analysis
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Preparation and Storage
Stability and Storage
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
Constituent: 99% PBS
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute with 250µl distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. It is recommended that the vial is gently mixed after reconstitution. Best use within three months from the date of reconstitution.
FGF inducible 14
Fibroblast growth factor inducible immediate early response protein 14
Fibroblast growth factor-inducible immediate-early response protein 14
Tumor necrosis factor receptor superfamily member 12A
FunctionReceptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Tissue specificityHighly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.