Recombinant human TWEAKR protein (ab125756)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
    • Molecular weight
      6 kDa
    • Amino acids
      28 to 80

Specifications

Our Abpromise guarantee covers the use of ab125756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Biological activity is determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-5.0ug/ml in the presence of 1ug/ml rhTWEAK.
  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Purity
    > 97 % SDS-PAGE.
    ab125756 is purified by proprietary chromatographic techniques. Purity is greater than 97.0% as determined by RP-HPLC and SDS-PAGE.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    pH: 7.40
    Constituent: 99% PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    It is recommended to reconstitute ab125756 in sterile ultra pure water not less than 100µg/ml, which can then be further diluted to other aqueous solutions. Upon reconstitution ab125756 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

General Info

  • Alternative names
    • CD 266
    • CD266
    • CD266 antigen
    • FGF inducible 14
    • FGF-inducible 14
    • Fibroblast growth factor inducible immediate early response protein 14
    • Fibroblast growth factor-inducible immediate-early response protein 14
    • FN 14
    • FN14
    • TNFRSF 12A
    • TNFRSF12A
    • TNR12_HUMAN
    • Tumor necrosis factor receptor superfamily member 12A
    • TWEAK R
    • Tweak receptor
    • Tweak-receptor
    • TweakR
    see all
  • Function
    Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
  • Tissue specificity
    Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
  • Sequence similarities
    Contains 1 TNFR-Cys repeat.
  • Cellular localization
    Membrane.
  • Information by UniProt

References

ab125756 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab125756.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up