The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityuseful for Antibody Production and Protein Array
Additional notesab112369 is best used within three months from the date of receipt.useful for Antibody Production and Protein Array
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced
Non receptor tyrosine protein kinase 2
Non receptor tyrosine protein kinase TYK2
Non-receptor tyrosine-protein kinase TYK2
Protein Tyrosine Kinase 2
Tyrosine kinase 2
FunctionProbably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Tissue specificityObserved in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Involvement in diseaseDefects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 1 protein kinase domain. Contains 1 SH2 domain.
DomainThe FERM domain mediates interaction with JAKMIP1.