Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      110 kDa including tags
    • Amino acids
      442 to 1187

Specifications

Our Abpromise guarantee covers the use of ab125539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    The specific activity of ab125539 was determined to be 24 nmol/min/mg.
  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Purity
    > 70 % Densitometry.
    Purity determined to be >70% by densitometry.
  • Form
    Liquid
  • Additional notes

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • JTK 1
    • JTK1
    • Non receptor tyrosine protein kinase 2
    • Non receptor tyrosine protein kinase TYK2
    • Non-receptor tyrosine-protein kinase TYK2
    • OTTHUMP00000232745
    • OTTHUMP00000232746
    • OTTHUMP00000232748
    • Protein Tyrosine Kinase 2
    • TYK 2
    • Tyk2
    • TYK2_HUMAN
    • Tyrosine kinase 2
    see all
  • Function
    Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
  • Tissue specificity
    Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
  • Involvement in disease
    Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
    Contains 1 FERM domain.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
  • Domain
    The FERM domain mediates interaction with JAKMIP1.
  • Information by UniProt

Recombinant human TYK2 protein images

  • SDS-PAGE analysis of ab125539.
  • The specific activity of ab125539 was determined to be 24 nmol/min/mg by Kinase Assay.

References for Recombinant human TYK2 protein (ab125539)

ab125539 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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