Recombinant Human Tyrosyl tRNA synthetase protein (ab123223)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      59 kDa
    • Amino acids
      1 to 528

Specifications

Our Abpromise guarantee covers the use of ab123223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.
    ab123223 was purified by conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 7.50
    Preservative: 2.04% Imidazole
    Constituents: 0.61% Tris, 2.92% Sodium chloride

General Info

  • Alternative names
    • CMTDIC
    • SYYC_HUMAN
    • Tyrosine tRNA ligase, cytoplasmic
    • Tyrosine tRNA ligase 1, cytoplasmic
    • Tyrosyl tRNA synthetase
    • Tyrosyl--tRNA ligase
    • Tyrosyl-tRNA synthetase, cytoplasmic
    • TyrRS
    • yars
    • YRS
    • YTS
    see all
  • Function
    Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
  • Involvement in disease
    Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
  • Sequence similarities
    Belongs to the class-I aminoacyl-tRNA synthetase family.
    Contains 1 tRNA-binding domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • 12.5% SDS Page analysis of ab123223

References

ab123223 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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