Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab90022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -80°C.

    pH: 8.00
    Constituents: 0.05% Tween, 0.0462% DTT, 20% Glycerol, 0.58% Sodium chloride, 0.395% Tris HCl

General Info

  • Alternative names
    • E1-L2
    • FLJ10808
    • FLJ23367
    • Monocyte protein 4
    • MOP 4
    • MOP-4
    • MOP4
    • UBA 6
    • Uba6
    • UBA6 ubiquitin activating enzyme E1
    • UBA6_HUMAN
    • UBE1L2
    • Ubiquitin activating enzyme 6
    • Ubiquitin activating enzyme E1 like 2
    • Ubiquitin activating enzyme E1 like protein 2
    • Ubiquitin like modifier activating enzyme 6
    • Ubiquitin-activating enzyme 6
    • Ubiquitin-activating enzyme E1-like protein 2
    • Ubiquitin-like modifier-activating enzyme 6
    see all
  • FunctionActivates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
  • Tissue specificityWidely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the ubiquitin-activating E1 family.
  • Information by UniProt

Recombinant Human Uba6 protein images

  • SDS-PAGE showing ab90022 at approximately 118kDa (3µg).

References for Recombinant Human Uba6 protein (ab90022)

ab90022 has not yet been referenced specifically in any publications.

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