Recombinant Human UBASH3A protein (ab162684)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MAAGETQLYAKVSNKLKGRSSPSLLEPLLAMGFPVHTALKALAATGRKTA EEALAWLHDHCNDPSLDDPIPQEYALFLCPTGPLLEKLQEFWRESKRQCA KNRAHEVFPHVTLCDFFTCEDQKVECLYEALKRAGDRLLGSFPTAVPLAL HSSISYLGFFVSGSPADVIREFAMTFATEASLLADCSVKPCTKQLHLTLA HKFYPHHQRTLEQLARAIPLGHSCQWTAALYSRDMRFVHYQTLRALFQYK PQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFLPENYTDR ASESDTWVKHRMYTFSLATDLNSRKDGEASSRCSGEFLPQTARSLSSLQA LQATVARKSVLVVRHGERVDQIFGKAWLQQCSTPDGNYYRPDLNFPCSLP RRSRGIKDFENDPPLSSCGIFQSRIAGMFEDCLVGKVTITATLIMASRHP A
    • Amino acids
      1 to 451
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab162684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Cbl interacting protein 4
    • Cbl-interacting protein 4
    • CLIP4
    • STS 2
    • STS-2
    • Suppressor of T cell receptor signaling 2
    • Suppressor of T-cell receptor signaling 2
    • T cell ubiquitin ligand
    • T cell ubiquitin ligand protein
    • T-cell ubiquitin ligand 1
    • TULA
    • TULA-1
    • UBASH3A
    • ubiquitin associated and SH3 domain containing, A
    • Ubiquitin-associated and SH3 domain-containing protein A
    • UBS3A_HUMAN
    see all
  • Function
    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
  • Tissue specificity
    Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
  • Sequence similarities
    Contains 1 SH3 domain.
    Contains 1 UBA domain.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt

Images

  • ab162684 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab162684 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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