Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD
    • Molecular weight
      18 kDa

Specifications

Our Abpromise guarantee covers the use of ab73540 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    Purity greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
  • Form
    Liquid
  • Additional notes
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 50mM HEPES, 150mM Sodium chloride, 1mM DTT, pH 7.5

General Info

  • Alternative names
    • E2 F1
    • L UBC
    • L-UBC
    • UB2L3_HUMAN
    • UBCE7
    • UbcH7
    • UbcM4
    • Ube2l3
    • Ubiquitin carrier protein L3
    • Ubiquitin conjugating enzyme E2 L3
    • Ubiquitin protein ligase L3
    • Ubiquitin-conjugating enzyme E2 L3
    • Ubiquitin-conjugating enzyme E2-F1
    • Ubiquitin-protein ligase L3
    see all
  • Function
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
  • Tissue specificity
    Ubiquitous, with highest expression in testis.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the ubiquitin-conjugating enzyme family.
  • Post-translational
    modifications
    Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation.
  • Cellular localization
    Nucleus. Cytoplasm.
  • Information by UniProt

References for Recombinant Human Ube2L3 protein (ab73540)

ab73540 has not yet been referenced specifically in any publications.

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