Recombinant Human UBE2V1 protein (Chemical Free) (ab81565)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ13404
    • SpeciesHuman
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab81565 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Conjugation

  • Purity> 95 % SDS-PAGE.

  • FormLyophilised
  • Additional notes

    Ubiquitin-conjugating Enzyme E2 Variant 1 (UBE2V1), is a member of the Ubiquitin-conjugating (E2) enzyme family.

    The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N (Ubc13), which mediates the synthesis of K63-linked Ubiquitin chains and is required for NF-κB activation.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, PBS, 1mM DTT, pH 7.2

General Info

  • Alternative names
    • CIR1
    • CROC-1
    • CROC1
    • CROC1A
    • TRAF6-regulated IKK activator 1 beta Uev1A
    • UB2V1_HUMAN
    • UBE2V
    • UBE2V 1
    • UBE2V1
    • Ubiquitin conjugating enzyme E2 variant 1
    • Ubiquitin-conjugating enzyme E2 variant 1
    • UEV-1
    • UEV1
    see all
  • FunctionHas no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
  • Tissue specificityHighly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.
  • Sequence similaritiesBelongs to the ubiquitin-conjugating enzyme family.
  • Cellular localizationNucleus. Excluded from the nucleolus.
  • Information by UniProt

References for Recombinant Human UBE2V1 protein (Chemical Free) (ab81565)

ab81565 has not yet been referenced specifically in any publications.

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