The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride
ReconstitutionReconstitute with water to desired concentration.
CTCL tumor antigen se37 2
CTCL tumor antigen se37-2
E6AP ubiquitin protein ligase
E6AP ubiquitin-protein ligase
HECT-type ubiquitin transferase E3A
Human papilloma virus E6 associated protein
Human papilloma virus E6 associated protein Angelman syndrome
Human papillomavirus E6-associated protein
NY REN 54 antigen
Oncogenic protein associated protein E6 AP
Oncogenic protein associated protein E6AP
Oncogenic protein-associated protein E6-AP
Renal carcinoma antigen NY REN 54
Renal carcinoma antigen NY-REN-54
Ubiquitin protein ligase E3A
Ubiquitin-protein ligase E3A
FunctionE3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
PathwayProtein modification; protein ubiquitination.