Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ05086
    • SpeciesHuman
    • Amino acids342 to 585

Specifications

Our Abpromise guarantee covers the use of ab126020 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • ReconstitutionReconstitute with water to desired concentration.

General Info

  • Alternative names
    • ANCR
    • Angelman syndrome
    • AS
    • CTCL tumor antigen se37 2
    • CTCL tumor antigen se37-2
    • E6 AP
    • E6AP
    • E6AP ubiquitin protein ligase
    • E6AP ubiquitin-protein ligase
    • EPVE6AP
    • FLJ26981
    • HECT-type ubiquitin transferase E3A
    • HPVE6A
    • Human papilloma virus E6 associated protein
    • Human papilloma virus E6 associated protein Angelman syndrome
    • Human papillomavirus E6-associated protein
    • NY REN 54 antigen
    • Oncogenic protein associated protein E6 AP
    • Oncogenic protein associated protein E6AP
    • Oncogenic protein-associated protein E6-AP
    • Renal carcinoma antigen NY REN 54
    • Renal carcinoma antigen NY-REN-54
    • UBE 3A
    • Ube3a
    • UBE3A protein
    • UBE3A_HUMAN
    • Ubiquitin protein ligase E3A
    • Ubiquitin-protein ligase E3A
    see all
  • FunctionE3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
  • PathwayProtein modification; protein ubiquitination.
  • Involvement in diseaseAngelman syndrome
  • Sequence similaritiesContains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Post-translational
    modifications
    Phosphorylation at Tyr-659 by ABL1 impairs E3 ligase activity and protects p53/TP53 from degradation in (HPV)-infected cells.
  • Cellular localizationNucleus. Cytoplasm.
  • Information by UniProt

References for Recombinant Human UBE3A protein (ab126020)

ab126020 has not yet been referenced specifically in any publications.

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