The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
600 kDa retinoblastoma protein associated factor
600 kDa retinoblastoma protein-associated factor
E3 ubiquitin-protein ligase UBR4
Retinoblastoma associated factor 600 like protein
Retinoblastoma associated factor of 600 kDa
Retinoblastoma-associated factor 600
Retinoblastoma-associated factor of 600 kDa
Ubiquitin protein ligase E3 component n recognin 4
Zinc finger UBR1 type protein 1
Zinc finger UBR1-type protein 1
Zinc finger, UBR1 type 1
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions.
Protein modification; protein ubiquitination.
Belongs to the UBR4 family. Contains 1 UBR-type zinc finger.
Membrane. Cytoplasm. Cytoplasm > cytoskeleton. Nucleus. Concentrates at the leading edge of membrane structures involved in actin motility.