Overview

  • Product name
    Recombinant Human UBXN6 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MKKFFQEFKADIKFKSAGPGQKLKESVGEKAHKEKPNQPAPRPPRQGPTN EAQMAAAAALARLEQKQSRAWGPTSQDTIRNQVRKELQAEATVSGSPEAP GTNVVSEPREEGSAHLAVPGVYFTCPLTGATLRKDQRDACIKEAILLHFS TDPVAASIMKIYTFNKDQDRVKLGVDTIAKYLDNIHLHPEEEKYRKIKLQ NKVFQERINCLEGTHEFFEAIGFQKVLLPAQDQEDPEEFYVLSETTLAQP QSLERHKEQLLAAEPVRAKLDRQRRVFQPSPLASQFELPGDFFNLTAEEI KREQRLRSEAVERLSVLRTKAMREKEEQRGLRKYNYTLLRVRLPDGCLLQ GTFYARERLGAVYGFVREALQSDWLPFELLASGGQKLSEDENLALNECGL VPSALLTFSWDMAVLEDIKAAGAEPDSILKPELLSAIEKLL
    • Amino acids
      1 to 441
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab164274 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • UBX domain containing 1
    • UBX domain containing 2
    • UBX domain containing protein 1
    • UBX domain containing protein 6
    • UBX domain protein 6
    • UBX domain-containing protein 1
    • UBX domain-containing protein 6
    • UBXD1
    • UBXDC2
    • Ubxn6
    • UBXN6_HUMAN
    see all
  • Function
    Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.
  • Tissue specificity
    Enhanced expression in testis.
  • Sequence similarities
    Contains 1 PUB (PUG) domain.
    Contains 1 UBX domain.
  • Domain
    The UBX domain lacks key residues critical for VCP binding.
  • Cellular localization
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes at the centrosome both in interphase and during mitosis.
  • Information by UniProt

Images

  • ab164274 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab164274 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab164274.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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