The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThis product is useful for Antibody Production and Protein Array
Additional notesThis product is useful for Antibody Production and Protein Array
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced.
E3 ubiquitin-protein ligase UHRF1
Inverted CCAAT box binding protein of 90 kDa
Inverted CCAAT box binding protein, 90-kD
Inverted CCAAT box-binding protein of 90 kDa
Liver regeneration-related protein LRRG126
Nuclear phosphoprotein, 95-KD
Nuclear protein 95
Nuclear zinc finger protein Np95
RING finger protein 106
Transcription factor ICBP90
Ubiquitin like containing PHD and RING finger domains protein 1
Ubiquitin like PHD and RING finger domain containing protein 1
Ubiquitin-like PHD and RING finger domain-containing protein 1
Ubiquitin-like protein containing PHD and RING finger domains 1
Ubiquitin-like with PHD and ring finger domains 1
Ubiquitin-like, containing PHD and RING finger domains, 1
Ubiquitin-like-containing PHD and RING finger domains protein 1
FunctionPutative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
Tissue specificityExpressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
PathwayProtein modification; protein ubiquitination.
Developmental stageExpressed in fetal thymus, liver and kidney.
DomainThe RING finger is required for ubiquitin ligase activity. The YDG domain mediates the interaction with histone H3.
Post-translational modificationsPhosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity. Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.