- Datasheet
- Specific References
- Protocols
Overview
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Product nameRecombinant Human ULBP2 protein
See all ULBP2 proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceEscherichia coli
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceMKHHHHHHASGRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYD CGNKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTP KEPLTLQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGA RKMKEKWENDKVVAMSFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAM S
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Molecular weight23 kDa including tags
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Amino acids26 to 216
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TagsHis tag N-Terminus
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Additional sequence informationMature form.
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab184602 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Mass Spectrometry
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Endotoxin level< 1.000 Eu/µg
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Mass spectrometryLC-MS/MS
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Purity>90% by SDS-PAGE.
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FormLyophilised
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.6
Constituent: Tris buffer
0.4 µm filtered prior to lyophilization. -
ReconstitutionAdd 200 µl of deionized water allow the lyophilized pellet dissolve completely.
General Info
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Alternative names
- ALCAN alpha
- ALCAN-alpha
- N2DL 2
see all -
FunctionLigand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
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Tissue specificityExpressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
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Sequence similaritiesBelongs to the MHC class I family.
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Cellular localizationCell membrane. Secreted.
- Information by UniProt
References
ab184602 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"