Recombinant Human UNC5B protein (ab109066)

Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      80 kDa
    • Amino acids
      28 to 363

Specifications

Our Abpromise guarantee covers the use of ab109066 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 95 % SDS-PAGE.

  • Form
    Lyophilised
  • Additional notes
    Binds to Mouse and Human Netrin 1.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

  • Reconstitution
    Reconstitute with 50 µl sterile water.

General Info

  • Alternative names
    • 6330415E02Rik
    • A630020F16
    • D10Bwg0792e
    • Netrin receptor UNC5B
    • Netrin receptor UNC5B Precursor
    • p53 regulated receptor for death and life
    • p53 regulated receptor for death and life protein 1
    • p53-regulated receptor for death and life protein 1
    • p53RDL1
    • Protein unc-5 homolog 2
    • Protein unc-5 homolog B
    • Protein XUNC 5
    • Transmembrane receptor Unc5H2
    • Unc 5 homolog 2
    • Unc 5 homolog B
    • Unc 5 netrin receptor B
    • UNC 5B
    • Unc5 (C.elegans homolog) b
    • Unc5b
    • UNC5B_HUMAN
    • UNC5H2
    see all
  • Function
    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
  • Tissue specificity
    Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
  • Sequence similarities
    Belongs to the unc-5 family.
    Contains 1 death domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 TSP type-1 domains.
    Contains 1 ZU5 domain.
  • Post-translational
    modifications
    Phosphorylated on cytoplasmic tyrosine residues.
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
    Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
  • Cellular localization
    Cell membrane. Membrane raft. Associated with lipid rafts.
  • Information by UniProt

References

ab109066 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

I can confirm that is ab109066 an Fc-Protein. The extracellular region of human UNC5B (aa 28-363) is fused at the C-terminus to the Fc portion of human IgG1.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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