Recombinant human uPA Receptor protein (ab191662)

Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      LRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEK TNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGS SDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYL PGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGN STHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHA HLGDAFSMNHIDVSCCTKSGCNHPDLDVQYR
    • Molecular weight
      32 kDa including tags
    • Amino acids
      23 to 303
    • Tags
      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab191662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    > 92 % SDS-PAGE.
    0.22 µm filtered
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at 4°C prior to reconstitution. Upon reconsitution add a carrier protein (0.1% BSA). Store at +4°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituents: 95% PBS, 5% Trehalose

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute the lyophilized product in sterile deionized water to a final concentration of 1 mg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage. After reconstitution store under sterile conditions for 3 months at -80°C.

General Info

  • Alternative names
    • CD 87
    • CD87
    • CD87 antigen
    • MO 3
    • MO3
    • Monocyte activation antigen Mo3
    • Plasminogen activator receptor urokinase
    • Plasminogen activator urokinase receptor
    • PLAUR
    • U PAR
    • u plasminogen activator receptor
    • U-PAR
    • u-plasminogen activator receptor form 2
    • UPA receptor
    • uPAR
    • UPAR_HUMAN
    • Urinary plasminogen activator receptor
    • URKR
    • Urokinase plasminogen activator receptor
    • Urokinase plasminogen activator surface receptor
    • urokinase-type plasminogen activator (uPA) receptor
    see all
  • Function
    Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
  • Tissue specificity
    Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
  • Sequence similarities
    Contains 3 UPAR/Ly6 domains.
  • Cellular localization
    Secreted and Cell membrane.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab191662 at >92% purity. DTT-reduced Human uPA Receptor protein migrates as 44-48 kDa due to glycosylation.

References

ab191662 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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