Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ9Y4E8-2
    • SpeciesHuman
    • Molecular weight24 kDa
    • Amino acids48 to 255
    • TagsHis-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab125983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • ReconstitutionReconstitute with water to desired concentration.

General Info

  • Alternative names
    • Deubiquitinating enzyme
    • Deubiquitinating enzyme 15
    • EC 3 1 2 15
    • KIAA0529
    • MGC131982
    • MGC149838
    • MGC74854
    • Ubiquitin Carboxy terminal Hydrolase 15
    • Ubiquitin carboxyl-terminal hydrolase 15
    • Ubiquitin specific peptidase 15
    • Ubiquitin specific processing protease 15
    • Ubiquitin Specific Protease 15
    • Ubiquitin thioesterase 15
    • Ubiquitin thiolesterase 15
    • Ubiquitin-specific-processing protease 15
    • UBP 15
    • UBP15
    • UBP15_HUMAN
    • Unph 2
    • UNPH 4
    • Unph-2
    • Unph2
    • Unph4
    • USP 15
    • Usp15
    see all
  • FunctionProtease that degrades 'Lys-48'-linked polyubiquitin chains. Protects target proteins against proteasomal degradation. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
  • Tissue specificityExpressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.
  • Sequence similaritiesBelongs to the peptidase C19 family.
    Contains 1 DUSP domain.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome.
    Ubiquitinated, leading to degradation by the proteasome.
  • Information by UniProt

References for Recombinant Human USP15 protein (ab125983)

ab125983 has not yet been referenced specifically in any publications.

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