The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20ºC.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride
ReconstitutionReconstitute with water to desired concentration.
Deubiquitinating enzyme 15
EC 3 1 2 15
Ubiquitin Carboxy terminal Hydrolase 15
Ubiquitin carboxyl-terminal hydrolase 15
Ubiquitin specific peptidase 15
Ubiquitin specific processing protease 15
Ubiquitin Specific Protease 15
Ubiquitin thioesterase 15
Ubiquitin thiolesterase 15
Ubiquitin-specific-processing protease 15
FunctionProtease that degrades 'Lys-48'-linked polyubiquitin chains. Protects target proteins against proteasomal degradation. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
Tissue specificityExpressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.
Sequence similaritiesBelongs to the peptidase C19 family. Contains 1 DUSP domain.
Post-translational modificationsPhosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome. Ubiquitinated, leading to degradation by the proteasome.