Vesicle associated membrane protein 4 isoform CRA a
Vesicle associated membrane protein 4 isoform CRA b
Vesicle-associated membrane protein 4
FunctionInvolved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.
Sequence similaritiesBelongs to the synaptobrevin family. Contains 1 v-SNARE coiled-coil homology domain.
Cellular localizationGolgi apparatus > trans-Golgi network membrane. Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.