VAMP vesicle associated membrane protein associated protein B and C
VAP B/VAP C
Vesicle associated membrane protein associated protein B and C
Vesicle associated membrane protein associated protein B/C
RelevanceVAPB contains 1 MSP domain and it may play a role in vesicle trafficking.
Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy [MIM:182980]; also called late onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late adult onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.
Cellular localizationCell membrane; Single-pass type IV membrane. Intracytoplasmic membrane; Single-pass type IV membrane protein. Note: Present in the plasma membrane and in intracellular vesicles.
Recombinant Human VAPB protein images
SDS-PAGE - VAPB protein (ab101214)
ab101214 at 3 µg analysed by 15% SDS PAGE.
References for Recombinant Human VAPB protein (ab101214)
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