Overview

  • Product name
    Recombinant Human Vav proteins
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      PFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDL MRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRF LKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERF LVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLM VPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDN ETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLL DKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQ GAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETT SCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKK DKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVEL TKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPME RAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLY RITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPA VGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYG RVGWFPANYVEEDYSEYC
    • Molecular weight
      120 kDa including tags
    • Amino acids
      73 to 845
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab172184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Purity
    > 70 % Densitometry.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.5
    Constituents: 73% Tris-HCl buffer, 25% Glycerol, 0.29% Sodium chloride, 0.31% Glutathione, 0.003% EDTA, 0.004% DTT, 0.002% PMSF

General Info

  • Alternative names
    • 2810040F13Rik
    • A530094I06Rik
    • AA986410
    • AI847175
    • FLJ40431
    • GDP/GTP exchange factor VAV2
    • Guanine nucleotide exchange factor VAV2
    • Guanine nucleotide exchange factor VAV3
    • MGC27838
    • Oncogene VAV
    • Oncogene VAV1
    • Oncogene VAV2
    • Oncogene VAV3
    • p95
    • p95vav
    • Protein vav 1
    • Protein vav 2
    • Protein vav 3
    • Proto oncogene vav
    • RGD1565941
    • VAV
    • vav 1 guanine nucleotide exchange factor
    • Vav 1 oncogene
    • vav 2 guanine nucleotide exchange factor
    • Vav 2 oncogene
    • vav 3 guanine nucleotide exchange factor
    • Vav 3 oncogene
    • vav-T
    • VAV1 oncogene
    • VAV2 oncogene
    • VAV3 oncogene
    see all
  • Relevance
    The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels. As a signalling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein. Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response.
  • Cellular localization
    Cytoplasmic and Plasma membrane VAV1, Cytoplasm - VAV2 & VAV3

Images

  • ab172184 on SDS-PAGE, MW ~120 kDa.

References

ab172184 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab172184.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up