The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityuseful for Antibody Production and Protein Array
Additional notesBest use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced
Cadherin 5 type 2
Cadherin 5, type 2 (vascular endothelium)
Cadherin 5, type 2, VE cadherin (vascular epithelium)
cadherin, vascular endothelial
cadherin, vascular endothelial, 1
Endothelial specific cadherin
Vascular endothelial cadherin
Vascular epithelium cadherin
FunctionCadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
Tissue specificityEndothelial tissues and brain.
Sequence similaritiesContains 5 cadherin domains.
Post-translational modificationsPhosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.
Cellular localizationCell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.