Recombinant Human VEGF Receptor 2 protein (ab106310)



  • NatureRecombinant
  • SourceInsect cells
  • Amino Acid Sequence
    • AccessionP35968
    • SpeciesHuman
    • SequenceThe soluble receptor protein consists of the first 6 extracellular domains and contains the unique C-terminal end of native Human soluble VEGF Receptor 2 (CGRETILDHSAEAVGMP) [Albuquerque et al.,Nature Medicine,2009] generated by alternative splicing.
    • Molecular weight105 kDa


Our Abpromise guarantee covers the use of ab106310 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityMeasured by its ability to bind to immobilized recombinant Human VEGF165 in a functional ELISA.
  • Applications

    Functional Studies


  • Purity> 95 % SDS-PAGE.

  • FormLyophilised
  • Additional notesEndotoxin level: < 0.1 ng per ug. Measured by its ability to bind to immobilized recombinant Human VEGF165 in a functional ELISA.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 25mM MES, 150mM Sodium chloride, pH 5.5

  • ReconstitutionThe lyophilized powder should be reconstituted in water or PBS to a concentration not lower than 100 µg/ml.

General Info

  • Alternative names
    • CD309
    • CD309 antigen
    • EC
    • Fetal liver kinase 1
    • FLK-1
    • FLK1
    • FLK1, mouse, homolog of
    • Kdr
    • Kinase insert domain receptor
    • Kinase insert domain receptor (a type III receptor tyrosine kinase)
    • KRD1
    • Ly73
    • Protein tyrosine kinase receptor FLK1
    • Protein-tyrosine kinase receptor flk-1
    • soluble VEGFR2
    • Tyrosine kinase growth factor receptor
    • Vascular endothelial growth factor receptor 2
    • VEGFR
    • VEGFR 2
    • VEGFR-2
    • VEGFR2
    see all
  • FunctionReceptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
  • Involvement in diseaseDefects in KDR are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Post-translational
    Phosphorylated. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-1214.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant Human VEGF Receptor 2 protein images

  • SDS-PAGE showing ab106310

References for Recombinant Human VEGF Receptor 2 protein (ab106310)

ab106310 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry regarding ab106041 and for taking the time to provide some useful details of the experiments. I am very sorry to hear that you are having problems with this antibody.

After reading through the detailed protocol you k...

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Thank you for contacting us.

The antibodies are viable for 10 years when stored at -20C, for 1 year when stored at 4C.

Please note that we recommend storing the antibodies at 4C for 1-2 weeks only. Some antibodies are prone to degrada...

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Thank you for your patience while I looked into your question. I have heard back from the lab, and ab106310 is also only the extracellular domain of VEGF receptor 2, and is thus not suitable for kinase studies. However, ab42614 has been tested ...

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