The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityMeasured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast. The ED50 for this effect is < 1ng/ml corresponding to a specific activity of less than 1,000,000 units/mg.
% SDS-PAGE. ab116402 was purified by proprietary chromatographic techniques and filter sterilized.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
pH: 7.50 Constituents: 10% Glycerol, 0.32% Tris HCl
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Vascular endothelial growth factor B
VEGF related factor
FunctionGrowth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Tissue specificityExpressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Sequence similaritiesBelongs to the PDGF/VEGF growth factor family.
Post-translational modificationsVEGF-B186 is O-glycosylated.
Cellular localizationSecreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.