Recombinant Human Vitamin D Receptor protein (ab82068)
Key features and details
- Expression system: Baculovirus infected insect cells
- Purity: > 95% HPLC
- Suitable for: GSA, WB
Description
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Product name
Recombinant Human Vitamin D Receptor protein -
Purity
> 95 % HPLC.
Affinity purified to >95% purity. -
Expression system
Baculovirus infected insect cells -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Amino acids
1 to 427
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab82068 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Gel Supershift Assays
Western blot
EMSA
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.9
Constituents: 0.75% Potassium chloride, 0.0154% DTT, 0.316% Tris HCl, 0.00584% EDTA, 20% Glycerol (glycerin, glycerine)
General Info
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Alternative names
- 1
- 1 25 dihydroxyvitamin D3 receptor
- 1,25 dihydroxyvitamin D3 receptor
see all -
Function
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. -
Involvement in disease
Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. -
Sequence similarities
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
Domain
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. -
Cellular localization
Nucleus. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab82068 has not yet been referenced specifically in any publications.