Vacuolar protein sorting 29 homolog (S. cerevisiae)
Vacuolar protein sorting associated protein 29
Vacuolar protein sorting-associated protein 29
Vacuolar sorting protein VPS29/PEP11
Vesicle protein sorting 29
x 007 protein
FunctionEssential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro).
Tissue specificityUbiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain.