This product is an active protein and may elicit a biological response in vivo, handle with caution.
Serine/threonine protein kinase VRK1
Serine/threonine-protein kinase VRK1
Vaccinia related kinase 1
Vaccinia virus B1R related kinase 1
Vaccinia-related kinase 1
FunctionSerine/threonine kinase that phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2.
Tissue specificityWidely expressed. Highly expressed in fetal liver, testis and thymus.
Involvement in diseaseDefects in VRK1 are the cause of pontocerebellar hypoplasia type 1 (PCH1) [MIM:607596]; also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1 is characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy (SMA).
Sequence similaritiesBelongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. Contains 1 protein kinase domain.
Post-translational modificationsAutophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53.
Cellular localizationNucleus. Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.