The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab111624 was denatured using detergent during conventional chromatography purification process.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 8.00 Constituents: 0.32% Tris HCl, 0.02% DTT, 2.4% Urea
DDB1- and CUL4-associated factor 7
Seven WD repeat protein of the AN11 family 1
WD repeat domain 68
WD repeat protein An11 homolog
WD repeat-containing protein 68
WD repeat-containing protein An11 homolog
FunctionInvolved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesBelongs to the WD repeat DCAF7 family. Contains 4 WD repeats.
Cellular localizationCytoplasm. Nucleus. Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.