The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
IL5 promoter REII region binding protein
MMSET type II
Multiple myeloma SET domain containing protein type III
Multiple myeloma SET domain protein
Multiple myeloma SET domain-containing protein
Nuclear receptor binding SET domain protein 2
Nuclear SET domain-containing protein 2
Probable histone-lysine N-methyltransferase NSD2
Trithorax/ash1 related protein 5
Wolf Hirschhorn syndrome candidate 1
Wolf Hirschhorn syndrome candidate 1 protein
Wolf-Hirschhorn syndrome candidate 1 protein
Probable histone methyltransferase (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription.
Involvement in disease
Note=A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH. Note=WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.