Overview

  • Product nameRecombinant human WISP1 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceTALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP WSPCSTSCGL GVSTRISNVN AQCWPEQESR LCNLRPCDVD IHTLIKAGKK CLAVYQPEAS MNFTLAGCIS TRSYQPKYCG VCMDNRCCIP YKSKTIDVSF QCPDGLGFSR QVLWINACFC NLSCRNPNDI FADLESYPDF SEIAN

Specifications

Our Abpromise guarantee covers the use of ab50041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityBiological Activity : The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 1.0-3.0 µg/ml.
  • Applications

    SDS-PAGE

    Functional Studies

  • Endotoxin level< 0.100 Eu/µg
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

    Preservative: None
    Constituents: 10mM Acetic acid

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionReconstitute product with 10mM Acetic Acid.

General Info

  • Alternative names
    • CCN 4
    • CCN family member 4
    • CCN4
    • WISP 1
    • WISP 1c
    • WISP 1i
    • WISP 1tc
    • WISP1c
    • WISP1i
    • WISP1tc
    • Wnt 1 induced secreted protein
    • WNT 1 induced secreted protein 1
    • WNT 1 inducible signaling pathway protein 1
    • Wnt 1 signaling pathway protein 1
    • Wnt-1 inducible signaling pathway protein 1
    • Wnt1 induced secreted protein
    • WNT1 induced secreted protein 1
    • WNT1 inducible signaling pathway protein 1
    • Wnt1 signaling pathway protein 1
    • WNT1-inducible-signaling pathway protein 1
    see all
  • RelevanceWISP1 is a downstream regulator in the Wnt/Frizzled-signaling pathway and is associated with cell survival. WISP1 attentuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X(L) protein. WISP1 is expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Overexpression is associated with several cancers including breast cancer and colon tumors.
  • Cellular localizationSecreted

References for Recombinant human WISP1 protein (ab50041)

This product has been referenced in:
  • Li WF  et al. WISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice. PLoS One 9:e94751 (2014). ICC/IF ; Mouse, Human . Read more (PubMed: 24728101) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"