Overview

Description

  • NatureRecombinant
  • SourceBaculovirus
  • Amino Acid Sequence
    • AccessionQ9H0M0
    • SpeciesHuman
    • Molecular weight106 kDa including tags
    • Amino acids2 to 922
    • TagsDDDDK tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab95931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -80°C.

    pH: 8.00
    Constituents: 20% Glycerol, 0.58% Sodium chloride, 0.395% Tris HCl, 0.05% Tween, 0.0462% DTT
    Note: 103 µg/ml FLAG peptide

General Info

  • Alternative names
    • AIP 5
    • AIP5
    • Atropin-1-interacting protein 5
    • hSDRP1
    • Nedd 4 like ubiquitin protein ligase
    • nedd4 like
    • NEDD4-like E3 ubiquitin-protein ligase WWP1
    • TGIF interacting ubiquitin ligase 1
    • Tiul1
    • WW domain containing E3 ubiquitin protein ligase 1
    • WW domain-containing protein 1
    • WWP 1
    see all
  • RelevanceWWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.
  • Cellular localizationCell Membrane, Cytoplasmic and Nuclear

Recombinant Human WWP1 protein images

  • 10% SDS-PAGE showing ab95931 at approximately 106kDa (1µg).

References for Recombinant Human WWP1 protein (ab95931)

ab95931 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95931.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"