The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Store at -80°C.
pH: 8.00 Constituents: 20% Glycerol, 0.58% Sodium chloride, 0.395% Tris HCl, 0.05% Tween, 0.0462% DTT Note: 103 µg/ml FLAG peptide
Atropin-1-interacting protein 5
Nedd 4 like ubiquitin protein ligase
NEDD4-like E3 ubiquitin-protein ligase WWP1
TGIF interacting ubiquitin ligase 1
WW domain containing E3 ubiquitin protein ligase 1
WW domain-containing protein 1
RelevanceWWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing.
The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.
Cellular localizationCell Membrane, Cytoplasmic and Nuclear
Recombinant Human WWP1 protein images
SDS-PAGE - WWP1 protein (Tagged) (ab95931)
10% SDS-PAGE showing ab95931 at approximately 106kDa (1µg).
References for Recombinant Human WWP1 protein (ab95931)
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