Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMSGEPGQ TSVAPPPEEV EPGSGVRIVV EYCEPCGFEA TYLELASAVK EQYPGIEIES RLGGTGAFEI EINGQLVFSK LENGGFPYEK DLIEAIRRAS NGETLEKITN SRPPC
    • Molecular weight
      15 kDa including tags
    • Amino acids
      1 to 112
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab168086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >95% by SDS-PAGE .
    ab168086 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names
    • C17orf37
    • C17orf37 homolog
    • C35
    • chromosome 17 open reading frame 37
    • HBV X transactivated gene 4 protein
    • HBV X-transactivated gene 4 protein
    • HBV XAg transactivated protein 4
    • HBV XAg-transactivated protein 4
    • MGC14832
    • Mien1
    • MIEN1_HUMAN
    • Migration and invasion enhancer 1
    • ORB3
    • Protein C17orf37
    • Protein C35
    • RDX12
    • Redox protein, 12-KD
    • XTP4
    see all
  • Function
    Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
  • Tissue specificity
    Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).
  • Sequence similarities
    Belongs to the SelWTH family.
  • Post-translational
    modifications
    Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.
  • Cellular localization
    Cytoplasm > cytosol. Cell membrane. Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab168086 (3µg).

References

ab168086 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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