This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cervical cancer suppressor gene 4 protein
Human cervical cancer suppressor gene 4 protein
Leucine zipper and sterile alpha motif containing kinase
Leucine zipper- and sterile alpha motif-containing kinase
Mitogen activated protein kinase kinase kinase MLT
Mitogen-activated protein kinase kinase kinase MLT
Mixed lineage kinase 7
Mixed lineage kinase related kinase
Mixed lineage kinase related kinase MRK beta
Mixed lineage kinase with a leucine zipper and a sterile alpha motif
Mixed lineage kinase-related kinase
MLK like mitogen activated protein triple kinase
MLK related kinase
MLK-like mitogen-activated protein triple kinase
Sterile alpha motif and leucine zipper containing kinase AZK
Sterile alpha motif- and leucine zipper-containing kinase AZK
FunctionStress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
Tissue specificityUbiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.
Cellular localizationCytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation.